Ethyl coumarin-3-carboxylate was synthesized from salicylaldehyde and diethyl malonate in absolute alcohol by Knoevenagel condensation reaction using hexahydropyridine as the catalyst. Hydrolysis of the reaction product with sodium hydroxide gave coumarin-3-carboxylic acid. 在无水乙醇中,以六氢吡啶为催化剂,通过水杨醛与丙二酸二乙酯的Knoevenagel缩合反应合成了香豆素-3-羧酸乙酯,再经水解、酸化得到香豆素-3-羧酸。